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KMID : 1038620220400010020
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Radiation Oncology Journal
2022 Volume.40 No. 1 p.20 ~ p.28
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PIVKA-II as a surrogate marker for prognosis in patients with localized hepatocellular carcinoma receiving stereotactic body radiotherapy
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Cho Ick-Joon
Jeong Jae-Uk
Nam Taek-Keun
Joo Young-Eun
Cho Sung-Bum
Kim Yong-Hyub
Song Ju-Young
Yoon Mee-Sun
Ahn Sung-Ja
Chung Woong-Ki
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Abstract
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Purpose: This study aimed to determine the correlation between protein induced by vitamin K absence or antagonist-II (PIVKA-II) and stereotactic body radiotherapy (SBRT) in patients with hepatocellular carcinoma (HCC).
Materials and Methods: Sixty-one patients received SBRT between 2015 and 2020 with a median dose of 48 Gy (range, 39 to 60 Gy) with a median of 4 fractions. Changes in tumor markers before and after SBRT were analyzed.
Results: The median follow-up period was 31 months (range, 12 to 64 months). The estimated 2-year in-field failure-free survival, progression-free survival (PFS), and overall survival rates were 82.0%, 39.3%, and 96.7%, respectively. Patients with decreased PIVKA-II levels through SBRT had significantly few in-field failures (p = 0.005). Patients with PIVKA-II levels of ≤25 mAU/mL after SBRT had significantly long PFS (p = 0.004).
Conclusion: PIVKA-II could be a useful surrogate marker for response or survival outcomes in patients with localized HCC receiving SBRT.
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KEYWORD
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Stereotactic body radiotherapy, Hepatocellular carcinoma, PIVKA-II
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